Application of HeLa cells in Animal Cell culture

• HeLa cells, like other cell lines, are termed "immortal“
• many strains of HeLa cells as they continue to mutate in cell cultures
• There are many strains of HeLa cells as they continue to mutate in cell cultures
• The total number of HeLa cells that have been propagated in cell culture far exceeds the total number of cells that were in Henrietta Lacks' body
• HeLa cells were used by Jonas Salk to test the first polio vaccine in the 1950s. 
• They were observed to be easily infected by poliomyelitis, causing infected cells to die.
•  HeLa cells have been used in testing how parvo virus infects cells of humans, HeLa, dogs, and cats.
• These cells have also been used to study viruses such as the oropouche virus (OROV). 
• OROV causes the disruption of cells in culture, where cells begin to degenerate shortly after they are infected, causing viral induction of apoptosis.
• Virus should inhibit apoptosis, in order to prolong the life of the cell and thereby maximize the number of progeny virions. 
• The host, on the other hand, should stimulate apoptosis thereby inhibiting viral growth and blocking viral spread. 
• For example, the function of the latent membrane protein 1 (LMP1) of the Epstein Barr virus and the bcl-2 homologue gene A179L of African swine fever virus is to inhibit apoptosis. 
• However, in other cases it is the virus that stimulates cell death